@article{oai:air.repo.nii.ac.jp:00001774,
 author = {Inomata, Shoko and Ito, Sachiko U and Wakasa, Masahiko and Osawa, Yukihiko and Shimizu, Kazumi and Ito, Wakako and Kanbayashi, Takashi and Shimizu, Tetsuo},
 issue = {2},
 journal = {秋田医学},
 month = {Dec},
 note = {The purpose of this study is to investigate whether often used hypnotics are safe or not to elderly
people by evaluating the early morning effects and residual effects on the physical and cognitive
functions after hypnotic administration.
Fourteen healthy elders (3 male, 11 female ; mean age 64 years) took part in the study. Triazolam
0.125 mg, rilmazafone hydrochloride 1 mg or placebo was orally given to each subject
before going to bed (11 pm). Objective evaluations including 1. Total Sway Path test (opened
and closed eye)　2. Functional Reach test　3. Timed Up and Go test　4. Simply Discriminatory
Reaction test　5. Critical Flicker Fusion test　6. Short-Term Memory test were done at 10 pm
(an hour before subjects went to bed), 4 am, 6 am, 10 am and 2 pm.
Among all evaluations for the physical and cognitive functions, main effects between medicines
were only seen in the Total Sway Path test, which is the indicator for static balance ability. When
eyes were opened, trembling was significantly small in the rilmazafon group compared to the placebo
group (p=0.04).
In this study, the hypnotics did not affect physical and cognitive functions for healthy elders. Further
studies using an interdisciplinary approach with different professionals such nurses, physical
therapists, pharmacists and physicians are needed for evaluating the safety use of hypnotics in the
elderly patients with insomnia.},
 pages = {63--69},
 title = {THE EFFECTS OF TRIAZOLAM AND RILMAZAFONE ON THE PHYSICAL AND COGNITIVE FUNCTIONS IN HEALTHY ELDERLY PERSONS},
 volume = {38},
 year = {2011}
}