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エイコサペンタエン酸は非アルコール性脂肪性肝炎を改善する
http://hdl.handle.net/10295/1798
http://hdl.handle.net/10295/1798a46f141c-5cc6-45b2-b4df-f57b48bc678d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
akitai37(29).pdf (2.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2011-10-18 | |||||||||
| タイトル | ||||||||||
| タイトル | エイコサペンタエン酸は非アルコール性脂肪性肝炎を改善する | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | non-alcoholic steatohepatitis | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Pten | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Eicosapentaenoic acid | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 作成者 |
石井, 元
× 石井, 元
× Ishii, Hajime
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| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Background/Aims:Eicosapentaenoic acid(EPA)has been known as a reagent for improving lip-Eicosapentaenoic acid(EPA)has been known as a reagent for improving lip-(EPA)has been known as a reagent for improving lip-EPA)has been known as a reagent for improving lip-)has been known as a reagent for improving lip-has been known as a reagent for improving lipid metabolism and inflammation. Hepatocyte-specific Pten-deficient mice exhibit hepatic lesions analogous to non-alcoholic steatohepatitis(NASH). Therefore, we administered EPA to Pten-deficient mice to investigate the mechanisms of NASH. Methods:Pten-deficient mice were assigned to a control group fed with a standard chow or an EPA group fed with a 5% EPA-supplemented standard chow. At 40 weeks, livers from each group were processed for measuring triglyceride content, gene expression analysis, Western blotting analysis, and histological examination. Level of serum reactive oxygen species (ROS) was also determined. Forty- and 76-week-old mice were used in tumor burden experiments. Results:EPA ameliorated hepatic steatosis in Pten-deficient mice based on decreased expression of AMPKα1-mediated SREBP-1c and increased PPARα expression. The EPA group exhibited less severe chronic hepatic inflammation compared to the control group, resulting from decreased ROS formation and a dramatically low ratio of arachidonic acid to EPA. Moreover, EPA inhibited development of hepatocellular carcinoma(HCC)in Pten-deficient mice based on an inhibition of MAPK activity and a low ratio of oleic to stealic acid, and a reduction in ROS formation. Conclusions:EPA ameliorated steatohepatitis and development of HCC in Pten-deficient mice. | |||||||||
| 言語 | en | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 書誌情報 |
ja : 秋田医学 巻 37, 号 1, p. 29-35, 発行日 2010-01-01 |
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| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 03866106 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN00009294 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 秋田医学会 | |||||||||
| 言語 | ja | |||||||||
