{"created":"2023-07-25T10:22:20.310438+00:00","id":1674,"links":{},"metadata":{"_buckets":{"deposit":"d1235023-74c3-41d4-960c-46f9fe9fb942"},"_deposit":{"created_by":15,"id":"1674","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"1674"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00001674","sets":["611:862:863:881"]},"author_link":["6137","6138","6139","6140","6141","6142","6143"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"202","bibliographicPageStart":"195","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"秋田医学","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Glucocorticoids, which are prescribed as anti-inflammatory agents, can cause secondary osteoporosis and skeletal muscle atrophy. We examined the effects of glucocorticoids on the muscle strength and muscle fatigability in rats. Six-month-old female Wistar rats were randomized into two groups : 1) the control group, which received daily injections of normal saline and 2) the predonisolone (PSL) group, which received PSL 10 mg/kg daily. After a 4-week treatment period, the maximum contractile strength (to measure muscle strength) and strength decrement index (SDI) (to measure muscle fatigue) were evaluated by contractile properties using three different stimulations : 1) 20-Hz tetanic, 2) 40-Hz tetanic, and 3) 100-Hz cyclical. The cross sectional area (CSA) was measured at the left tibialis anterior (TA) muscle. Contractile muscle strength by 40-Hz tetanic stimulation, but not the other stimulations, significantly decreased in the PSL groups compared to the control group; decreases occurred in a time-dependent manner (p<0.05). The SDI in the 40-Hz stimulation was significantly increased in the PSL group compared to the control group (p<0.05). The CSA of the TA muscle in the PSL group was significantly smaller than in the control group (p<0.05). These results suggest that glucocorticoids cause a decrease in the muscle strength, a smaller fiber CSA, and an increase in muscle fatigability in the calf muscle of rats. A 40-Hz tetanic stimulation is the appropriate condition to observe contractile muscle strength or fatigue in glucocorticoid-treated rats.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田医学会","subitem_publisher_language":"ja"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1724099666130":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"03866106","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00009294","subitem_source_identifier_type":"NCID"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SASAKI, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6137","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MIYAKOSHI, Naohisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6138","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KASUKAWA, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6139","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MAEKAWA, Shigeto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6140","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NOGUCHI, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6141","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAMO, Keiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6142","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SHIMADA, Yoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6143","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"akitai36(195).pdf","filesize":[{"value":"534.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"akitai36(195).pdf","url":"https://air.repo.nii.ac.jp/record/1674/files/akitai36(195).pdf"},"version_id":"1ca8cb04-eae9-42b9-aaf7-a2cd93e922ec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"glucocorticoids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"muscle strength","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"muscle fatigue","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rats","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"MUSCLE STRENGTH AND FATIGUE IN GLUCOCORTICOID-TREATED RATS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MUSCLE STRENGTH AND FATIGUE IN GLUCOCORTICOID-TREATED RATS","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["881"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-06-23"},"publish_date":"2011-06-23","publish_status":"0","recid":"1674","relation_version_is_last":true,"title":["MUSCLE STRENGTH AND FATIGUE IN GLUCOCORTICOID-TREATED RATS"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-08-25T08:47:02.607279+00:00"}