| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2011-06-23 |
| タイトル |
|
|
タイトル |
MUSCLE STRENGTH AND FATIGUE IN GLUCOCORTICOID-TREATED RATS |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
glucocorticoids |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
muscle strength |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
muscle fatigue |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
rats |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
SASAKI, Hiroshi
MIYAKOSHI, Naohisa
KASUKAWA, Yuji
MAEKAWA, Shigeto
NOGUCHI, Hideaki
KAMO, Keiji
SHIMADA, Yoichi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Glucocorticoids, which are prescribed as anti-inflammatory agents, can cause secondary osteoporosis and skeletal muscle atrophy. We examined the effects of glucocorticoids on the muscle strength and muscle fatigability in rats. Six-month-old female Wistar rats were randomized into two groups : 1) the control group, which received daily injections of normal saline and 2) the predonisolone (PSL) group, which received PSL 10 mg/kg daily. After a 4-week treatment period, the maximum contractile strength (to measure muscle strength) and strength decrement index (SDI) (to measure muscle fatigue) were evaluated by contractile properties using three different stimulations : 1) 20-Hz tetanic, 2) 40-Hz tetanic, and 3) 100-Hz cyclical. The cross sectional area (CSA) was measured at the left tibialis anterior (TA) muscle. Contractile muscle strength by 40-Hz tetanic stimulation, but not the other stimulations, significantly decreased in the PSL groups compared to the control group; decreases occurred in a time-dependent manner (p<0.05). The SDI in the 40-Hz stimulation was significantly increased in the PSL group compared to the control group (p<0.05). The CSA of the TA muscle in the PSL group was significantly smaller than in the control group (p<0.05). These results suggest that glucocorticoids cause a decrease in the muscle strength, a smaller fiber CSA, and an increase in muscle fatigability in the calf muscle of rats. A 40-Hz tetanic stimulation is the appropriate condition to observe contractile muscle strength or fatigue in glucocorticoid-treated rats. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 36,
号 3-4,
p. 195-202,
発行日 2010-03-01
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| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai36(195).pdf (534.8 kB)
