| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-12-01 |
| タイトル |
|
|
タイトル |
OVEREXPRESSION OF PROGRANULIN INCREASES CELLS IN GROWTH PHASE, BUT IS INSUFFICIENT TO INDUCE SKIN TUMOR FORMATION |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
progranulin |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
growth factor |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
signal transduction |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
tumorigenesis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
KATO, Maki
HASUNUMA, Naoko
ITAMI, Satoshi
MANABE, Motomu
OSADA, Shin-Ichi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Progranulin (PGRN), a multifunctional secreted growth factor, is highly expressed in various types of human cancers. However, it is still unknown whether upregulation of PGRN is a cause or a result of cancerous transformation. To assess the consequences of enhanced PGRN expression in vivo, we generated transgenic mice in which PGRN is specifically expressed in keratinocytes using the Cre/lox system. PGRN overexpression in the epidermis promoted the entry of basal cells to the proliferation phases, as revealed by Ki-67 immunostaining, but was insufficient to facilitate it to the mitotic phase, as revealed by phosphohistone H3 immunoreactivity. Accordingly, we observed no significant difference in the incidence of spontaneously occurring and chemically induced skin tumors between the transgenic and wild-type mice. These results suggest that overexpression of PGRN alone is insufficient to cause cancerous transformation of keratinocytes. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 36,
号 1,
p. 35-43,
発行日 2009-06-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
p35-43.pdf (1.7 MB)
