| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-01-22 |
| タイトル |
|
|
タイトル |
Bone Conductive and Inductive Effects of Poly(L-Lactid and ε-Caprolactone) / Hydroxyapatite Composites and Bone Morphogenetic Protein-2 in Rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bone |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hydroxyapatite |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
biodegradable copolymer |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bone morphogenetic protein-2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
NOGUCHI, Hideaki
MIYAKOSHI, Naohisa
SASAKI, Hiroshi
KAMO, Keiji
SHIMADA, Yoichi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Hydroxyapatite(HA)with copolymer of L-lactide andε-caprolactone［HA/P(LA/ CL)］is expected to be a potent biomaterial for orthopedic surgeries. Bone morphogenetic protein-2(BMP-2)has bone-inducing capability. In this in vivo study,we evaluated osteoconductivity(newly formed bone surrounding the implanted material) and osteoinductivity(newly formed bone in the implanted material)of HA/P(LA/CL) alone or combined with BMP-2 in cancellous bone in 7-month-old Sprague-Dawley rats. Surgical osteotomy in the sagittal orientation was performed on the proximal tibia and HA/P(LA/CL)alone or combined with BMP-2(1 or 10μg/block)was implanted to contact with the osteotomized cancellous bone surface. Four and eight weeks postsurgery, bone specimens at the operated sites were harvested and osteoconductivity and osteoinductivity were evaluated with quantitative histomorphometrical method. HA/P (LA/CL)block alone showed osteoconductivity from the week four but did not show osteoinductivity. Combination of HA/P(LA/CL) block and BMP-2 showed both osteoconductivity and osteoinductivity in a dose and time dependent manner. Because of its strong osteoconductivity and osteoinductivity,combination of HA/P(LA/CL)and BMP-2 might have potential clinical applications. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 35,
号 2,
p. 147-154,
発行日 2008-11-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akigaku35-2f.pdf (939.5 kB)
