| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-01-18 |
| タイトル |
|
|
タイトル |
The Negatively Activating Potassium Conductance of Rat Cochlear Hair Cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
potassium channels |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
outer hair cells |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
cochlear |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
whole-cell recording |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Wong, Weng Hoe
Eatock, Ruth Anne
ISHIKAWA, Kazuo
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Potassium channels are substantial to regulate electrical signaling and the ionic composition of biological fluids. It has also been suggested that mutations in the KCNQ4 K+ channel gene are responsible for autosomal dominant nonsyndromic hearing impairment (DFNA2). Negatively activating potassium (K+) conductance in rodent cochlear hair cells called gK,n, comprises KCNQ4 subunit, member of the KCNQ family of K+ channels. This conductance is important in setting the hair cells' resting potentials and input conductances. Here we try to examine the biophysical l?roperties of the conductance base on the voltage dependence, stability during whole-cell recording and permeability to Cs+. gK.n was proved to exist in rat outer hair cells that it was blocked by KCNQ4 blocker, linopirdine and has a significantly negative (mean Vl/2 = - 91.2 ± 1.06 mV) and broad (mean S-value= -12 ± 0.46 mV) voltage range of activation (n =24). However, gK,n does not show any permeability to Cs+ but only leak residual conductance with mean of 1.6± 0.44 nS (n =6). gK,n is stable i.e., its properties do not change ("wash out") despite of the replacement of internal solution with pipette solution during whole-cell recordings. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
秋田医学
巻 31,
号 1,
p. 53-62,
発行日 2004-05-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
akigaku31-1e.pdf (448.5 kB)
