{"created":"2023-07-25T10:22:11.852942+00:00","id":1482,"links":{},"metadata":{"_buckets":{"deposit":"e21b07ed-922d-47ba-aa8c-49043b52a999"},"_deposit":{"created_by":3,"id":"1482","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1482"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00001482","sets":["611:612:613:852"]},"author_link":["5349","5348"],"item_10002_alternative_title_34":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Possible function of protease on brain plasticity"}]},"item_10002_biblio_info_36":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"23","bibliographicPageStart":"16","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"秋田大学医学部保健学科紀要"}]}]},"item_10002_description_29":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"神経科学の領域で, 記憶学習の分子メカニズムは神経細胞の可塑性の原理に基づいていると考えられている. 神経\n可塑性は代謝的および構造的な変化を通じて神経細胞間の伝達効率が加減される現象である. この現象は, 多くの細\n胞内情報伝達因子, 遺伝子発現調節因子, 神経伝達物質の受容体や接着因子等によって生じることが明らかにされて\nきた. 最近, 新たにシナプスレベルにおけるプロテアーゼの関与が研究されてきたので神経可塑性とプロテアーゼに\nついて概説する.Synaptic plasticity is widely accepted as a fundamental hypothesis for learning and memory. The\ncandidate molecules for synaptic plasticity is now being elucidated in the field of neuroscience. Recent\nstudies reveal that proteases and their inhibitors in the nervous system play a role in neuronal processes\nrelated to synaptic plasticity, maintenances of extracellular environment and neuronal damages (including\nischemia and familial dementia). This paper focuses on typical and well-studied proteases and protease\ninhibitors. Therefore, tissue type-plasminogen activator, novel serine protease, neuropsin, and serine\nprotease inhibitor, neuroserpin are discussed.","subitem_description_type":"Other"}]},"item_10002_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田大学医学部保健学科"}]},"item_10002_source_id_27":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13478664","subitem_source_identifier_type":"ISSN"}]},"item_10002_source_id_35":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11834061","subitem_source_identifier_type":"NCID"}]},"item_10002_version_type_37":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"百田, 芳春"}],"nameIdentifiers":[{"nameIdentifier":"5348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MOMOTA, Yoshiharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5349","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"hoken16-2c.pdf","filesize":[{"value":"797.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"hoken16-2c.pdf","url":"https://air.repo.nii.ac.jp/record/1482/files/hoken16-2c.pdf"},"version_id":"49f389ab-f027-4b36-9898-e0a7bf14f92e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"セリンプロテアーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"神経可塑性","subitem_subject_scheme":"Other"},{"subitem_subject":"記憶","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"神経可塑性とプロテアーゼ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経可塑性とプロテアーゼ"}]},"item_type_id":"10002","owner":"3","path":["852"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-12-03"},"publish_date":"2008-12-03","publish_status":"0","recid":"1482","relation_version_is_last":true,"title":["神経可塑性とプロテアーゼ"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T11:51:18.697466+00:00"}