2026-03-12T20:46:52Z https://air.repo.nii.ac.jp/oai

oai:air.repo.nii.ac.jp:00002016 2024-08-25T08:06:36Z 611:862:863:937

AGE- RELATED CHANGES IN ELECTROPHYSIOLOGICAL PROPERTIES CBA/N MICE UTRICULAR TYPE II HAIR CELLS Koizumi, Kou Omi, Eigo Angunsri, Nakarin Honda, Kohei Ono, Kyoichi Ishikawa, Kazuo vestibular organ utricle, hair cell voltage-gated conductance inner-ear aging Objective This study investigated vestibular functional declination with age, leading to age-related deterioration of balance function. It has been shown that the impaired vestibular function is derived from structural and/or functional degeneration of vestibular hair cells. Methods We quantitatively analyzed the number of hair cells in the utricle of CBA/N mice at 2 different ages (5 weeks old and 26 weeks old) using immunohistochemistry. In addition, electrophysiological properties of type II hair cells were evaluated by the patch clamp method. Results We found a significant difference in the number of hair cells between the two groups, i.e., the number of hair cells was significantly less in the adult group than in the young group. Electrophysiological experiments revealed that the current density of the delayed rectifier K^+ current was significantly lower in adult mice than in young mice, with little change in activation kinetics. Conclusions These findings suggest that not only hair cell loss but also alterations in hair cell functions, resulting from aging, is involved in balance dysfunction. journal article 秋田医学会 2013-02-28 VoR application/pdf 秋田医学 2 39 81 87 https://air.repo.nii.ac.jp/record/2016/files/akitai39(81).pdf http://hdl.handle.net/10295/2157 https://air.repo.nii.ac.jp/records/2016 eng open access