2026-03-09T09:36:47Z https://air.repo.nii.ac.jp/oai

oai:air.repo.nii.ac.jp:00001648 2024-08-25T08:46:45Z 611:862:863:877

EFFECT OF MODEST PERIOPERATIVE INTAKE OF IMMUNO-NUTRITION RICH IN ω -3 POLYUNSATURATED FATTY ACIDS ON IL-10 IN ESOPHAGEAL CANCER PATIENTS Okuyama, Manabu Motoyama, Satoru Maruyama, Kiyotomi Sasaki, Kenji Sato, Yusuke Ogawa, Jun-ichi open access esophagectomy esophageal cancer immuno-nutrition IL-10 ω -3 Polyunsaturated Fatty Acids Background Recent trials have shown that perioperative administration of an immuno-enhancing diet can reduce the incidence of infectious complications and shorten hospital stay following elective surgery. The purpose of this study was to evaluate whether a relatively small perioperative intake of ω -3 polyunsaturated fatty acid (PUFA)-rich nutritional supplement modulates postoperative inflammatory responses. Methods Twenty-three patients with esophageal cancer were prospectively randomized into Treatment (n=11) and Control (n=12) groups. The former drank 2 packs (0.4 L) of a liquid diet that was supplemented with ω -3 fatty acids each day for 6 consecutive days prior to esophagectomy, while the latter drank a control liquid. In addition, both groups received postoperative enteral feeding with the same formula. The levels of human leukocyte antigen-DR (HLA-DR), interleukin (IL)-6 and IL-10 were measured, and polymorphonuclear cell and total lymphocyte counts were obtained. Results Plasma IL-10 levels were significantly (p<0.05) higher in the Treatment group than the Control group after beginning supplemental nutrition. By contrast, postoperative IL-6 levels tended to lower in the Treatment group, but the difference did not reach the level of significance. Conclusions Preoperative oral intake of a small amount of ω -3 PUFA-rich nutritional supplement increased postoperative IL-10 expression. 秋田医学会 2009-11-01 eng journal article VoR http://hdl.handle.net/10295/1672 https://air.repo.nii.ac.jp/records/1648 秋田医学 36 2 123 132 https://air.repo.nii.ac.jp/record/1648/files/p123-132.pdf application/pdf 873.3 kB 2017-02-16