2026-03-12T19:50:35Z https://air.repo.nii.ac.jp/oai

oai:air.repo.nii.ac.jp:00005747 2024-09-20T02:59:51Z 611:862:863:1486

ACTH 療法中に新たな発作を認め，benzodiazepine-induced seizure と考えられたWest 症候群の1例 A Case of West Syndrome that Appears New Seizures that is Probably Induced by Benzodiazepine During ACTH Therapy 山本, 達彦 Yamamoto, Tatsuhiko 渡辺, 圭介 Watanabe, Keisuke 矢野, 珠巨 Yano, Tamami 高橋, 勉 Takahashi, Tsutomu open access West syndrome drug-induced seizure benzodiazepine West syndrome is an age-dependent epileptic encephalopathy that occurs in infants and toddlers.　We present a case of a 7-month-old girl noted to have a specific facial appearance after birth and who was diagnosed with a 21-trisomy on chromosome testing.　She had epileptic spasm at around 7 months of age and EEG test revealed hypsarrhythmia.　The patient was diagnosed with West syndrome and was referred to our hospital for further investigation, where she was admitted and clonazepam （CZP） was prescribed.　ACTH therapy commenced and the patient showed improvement based on EEG findings and decreased epileptic spasm.　However, tonic seizures appeared with fast-wave rhythms on EEG.　Believing that this seizure was not epileptic spasm, we suspected benzodiazepine-induced seizure（BIS） as previously reported and reduced the CZP.　 The fast-wave rhythms disappeared and the seizures were decreased.　If new seizures are observed during treatment of West syndrome, we need to differentiate the BIS. 秋田医学会 2022-06-30 jpn journal article VoR https://doi.org/10.20569/00006059 http://hdl.handle.net/10295/00006059 https://air.repo.nii.ac.jp/records/5747 10.20569/00006059 0386-6106 AN00009294 秋田医学 Akita journal of medicine 49 1 65 68 https://air.repo.nii.ac.jp/record/5747/files/akitai49_1(65).pdf application/pdf 1.0 MB 2022-07-19