2026-03-14T23:01:11Z https://air.repo.nii.ac.jp/oai

oai:air.repo.nii.ac.jp:00005425 2024-08-25T04:14:35Z 611:939:940

Outcomes of definitive chemoradiotherapy for stage iva (T4b vs. n4) esophageal squamous cell carcinoma based on the japanese classification system: A retrospective single-center study Wada, Yuki Anbai, Akira Takagi, Noriko Kumagai, Satoshi Okuyama, Eriko Nanjo, Hiroshi Sato, Yusuke Motoyama, Satoru Hashimoto, Manabu open access Copyright: c2020 by the authors. LicenseeMDPI,Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the CreativeCommonsAttribution (CCBY) license (https://creativecommons.org/licenses/by/4.0/). esophageal squamous cell carcinoma definitive chemoradiation therapy external beam radiation therapy locally advanced esophageal cancer The differences in prognoses or progression patterns between T4b non-N4 and non-T4b N4 esophageal squamous cell carcinoma post chemoradiotherapy (CRT) is unclear. This study compared the outcomes of CRT for stage IVa esophageal squamous cell carcinoma according to T/N factors. We retrospectively identified 66 patients with stage IVa esophageal squamous cell carcinoma who underwent definitive CRT at our center between January 2009 and March 2013. The treatment outcomes, i.e., progression patterns, prognostic factors, and toxicities based on version 5.0 of the National Cancer Institute Common Terminology Criteria for Adverse Events, were studied. The patients (56 men and 10 women) had a median age of 67 (range: 37–87) years. The T/N classifications were T4b non-N4 (28/66), non-T4b N4 (24/66), and T4b N4 (14/66). Objective response was achieved in 57 patients (86.4%, (95% confidence interval, 74.6–94.1%)). There were no significant differences between the T/N groups in terms of overall survival, progression-free survival, and progression pattern. We found no significant differences in prognoses or progression patterns among patients with T4b non-N4, non-T4b N4, and T4b N4 esophageal squamous cell carcinoma. Thus, it seems impractical to modify CRT regimens based on T/N factors. MDPI 2021 eng journal article VoR http://hdl.handle.net/10295/00005747 https://air.repo.nii.ac.jp/records/5425 https://dx.doi.org/10.3390/cancers13010008 2072-6694 Cancers 13 1 https://air.repo.nii.ac.jp/record/5425/files/iA_2021_25.pdf application/pdf 445.3 kB 2021-08-10