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冬眠動物における頚動脈小体の季節変化について Seasonal changes on the carotid body in the hibematable animals 大友, 和夫 福原, 紅子 吉崎, 克明 OHTOMO, Kazuo FUKUHARA, Kohko YOSHIZAKI, Katsuaki carotid body hibernation immunohistochemistry electron microscopy The carotid body as an arterial chemosensory organ regulates respiration, and its parenchymal cells contain several neuropeptides. Therefore, it would be of interest to identify differences in the physiological state and the distribution of several neuropeptides between hibernating and nonhibernating animals. We examined immunohistochemically the distribution of several neuropeptides in the carotid bodies of two mammalian species to study the role of the organ in the hibernation, focusing on differences in the vital signs between the hibernation and nonhibernation periods. Hibernation represents a physiological adaptation to the severe environment during winter. Vital signs such as respiration rate, heart rate and body temperature in hibernating animals are markedly decreased and the depression and heart rate in particular could result in hypoxia. Respiration rate and heart rate during hibernation were less than one tenth of those during nonhibernation. Intense immunoreactivities for tyrosine hydroxylase(TH) and glutamate(Glu) was observed as small groups in the glomus cells of the carotid body during the non-hibernation phase. In the hibenating animals, mild. methionin-enkephaline(Met-Enk) immunoreactivities were evident in almost all glomus cells and some nerve fibers. In the electron microscopic observation,the visible difference of the size and morphology observed the mitochondoria in glomus cells of the both animals. 秋田大学医療技術短期大学部 1999-01-01 jpn departmental bulletin paper VoR http://hdl.handle.net/10295/1453 https://air.repo.nii.ac.jp/records/1473 09187812 AN10408365 秋田大学医療技術短期大学部紀要 7 2 109 116 https://air.repo.nii.ac.jp/record/1473/files/otm-1.pdf application/pdf 1.2 MB 2017-02-16