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A Case of Atopic Cough Successfully Treated with the H1 Antagonist Epinastine Hydrochloride 塩酸エピナスチンが有効だったアトピー咳嗽の1例 Shioya, Takanobu Sano, Masaaki Kagaya, Manabu Ito, Takefumi Watanabe, Akiko Fukui, Shin Sasaki, Masahiro Ito, Hiroshi 塩谷, 隆信 佐野, 正明 加賀谷, 学 伊藤, 武史 渡邊, 亜紀子 福井, 伸 佐々木, 昌博 伊藤, 宏 epinastine hydrochloride histamine H1 antagonist atopic cough eosinophilic bronchitis capsaicin cough threshold eosinophilic inflammation 慢性咳嗽を訴える38歳の女性がアトピー咳嗽(好酸球性気管支炎)と診断された.ヒスタミンH1拮抗薬である塩酸エピナスチン(エピナスチン;1日1回20mg投与)の効果を確かめる目的で,咳点数,呼吸機能,カブサイシン咳閾値,メサコリンに対する気道過敏性を,エビナスチン投与前と投与4週後に評価した.エビナスチン投与後,咳嗽は著明に減少し,さらに,カブサイシン咳閾値は顕著に改善した.これらの結果から,エビナスチンがアトピー咳嗽患者の治療に有用であり,アトピー咳嗽の病態生理にヒスタミン受容体が関与している可能性が示唆された. A 38-year-old female patient with chronic persistent cough was diagnosed with atopic cough (eosinophilic bronchitis). To investigate the effect of a H1 antagonist epinastine hydrochloride (epinastine; 20mg/day, once daily), we evaluated cough scores, pulmonary function, capsaicin cough threshold, and bronchial hyperresonsiveness to methacholine before and after a 4-week treatment with epinastine. Treatment with epinastine resulted in a marked decrease in persistent cough. It also resulted in a marked improvement in capsaicin cough threshold. These results suggested that epinastine may be useful for treating patients with atopic cough and that histamine HI receptor is related to the pathophysiology of atopic cough. 秋田大学医学部 2004-03-31 eng departmental bulletin paper VoR http://hdl.handle.net/10295/290 https://air.repo.nii.ac.jp/records/581 13478664 AA11834061 秋田大学医学部 保健学科紀要 12 1 72 77 https://air.repo.nii.ac.jp/record/581/files/KJ00004257421.pdf application/pdf 604.5 kB 2017-02-16