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Regulatory T Cell as a Biomarker of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia
http://hdl.handle.net/10295/00006219
http://hdl.handle.net/10295/00006219957a20e2-a6dc-41e4-9568-f3dc408f4a36
名前 / ファイル | ライセンス | アクション |
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iA_2022_76.pdf (2.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2023-02-23 | |||||
タイトル | ||||||
タイトル | Regulatory T Cell as a Biomarker of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic myeloid leukemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | imatinib | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | treatment-free remission | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | regulatory T cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Fujioka, Yuki
× Fujioka, Yuki× Sugiyama, Daisuke× Matsumura, Itaru× Minami, Yosuke× Miura, Masatomo× Atsuta, Yoshiko× Ohtake, Shigeki× Kiyoi, Hitoshi× Miyazaki, Yasushi× Nishikawa, Hiroyoshi× Takahashi, Naoto |
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内容記述(抄録) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Simple Summary Tyrosine kinase inhibitors (TKIs) have dramatically improved the treatment of chronic myeloid leukemia (CML). Recently, TKIs were discontinued in patients with CML with deep molecular remission, and some patients have been reported to be able to maintain long-term treatment-free remission (TFR). However, there is no certainty regarding which patients can maintain TFR. We focused on immunity in the TFR phase and investigated the immunological mechanism of continuous TFR or recurrence. Our results suggest that the group that maintains the TFR is immunologically activated. In addition, regulatory T cells can be used as a biomarker. These results may have important implications for future strategies for maintaining TFR in CML treatment. Treatment-free remission (TFR) has become a therapeutic goal in chronic myeloid leukemia (CML), and approximately half of the patients with chronic phase-CML (CML-CP) with deep molecular remission (DMR) by tyrosine-kinase inhibitors (TKIs) have achieved TFR. However, the mechanism of continuous TFR is still unclear, as there are fluctuate patients who have BCR-ABL-positive leukemia cells but do not observe obvious relapse. We focused on the immune response and conducted an immune analysis using clinical samples from the imatinib discontinuation study, JALSG-STIM213. The results showed that, in the group that maintained TFR for 3 years, changes in regulatory T (Treg) cells were observed early after stopping imatinib treatment. The effector Treg (eTreg) cells increased transiently at 1 month after stopping imatinib and then returned to baseline at 3 months after stopping imatinib treatment. There was no difference in the Treg phenotype, and CD8(+) T cells in the TFR group were relatively activated. High concentrations of imatinib before stopping were negatively correlated with eTreg cells after stopping imatinib. These data suggest immunological involvement in the maintenance of the TFR, and that Treg cells after stopping imatinib might be a biomarker for TFR. Furthermore, high imatinib exposure may have a negative immunological impact on the continuous TFR. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/cancers13235904 | |||||
書誌情報 |
CANCERS 巻 13, 号 23, 発行日 2021 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2072-6694 | |||||
出版者 | ||||||
出版者 | MDPI | |||||
関連リンク | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.3390/cancers13235904 | |||||
関連名称 | http://dx.doi.org/10.3390/cancers13235904 | |||||
著作権等 | ||||||
権利情報 | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |