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The preventive effects of RIPC in patients not at high risk of CI-AKI were examined, and biomarkers with anticipated roles in renal protection via RIPC investigated. Methods and Results: Sixty patients who had moderate chronic kidney disease and who underwent angiography were randomly assigned to the control (n=30) or RIPC (intermittent arm ischemia, n=30) group. The baseline characteristics in the 2 groups did not differ significantly. CI-AKI was evaluated by measuring urinary liver-type fatty acidbinding protein (L-FABP). Biomarkers were measured before and 24 and 48 h after angiography. Twenty-four hours after angiography, the percent change in urinary L-FABP level in the RIPC group was significantly smaller than in the control group (41.3±15.6 vs. 159±34.1%, P=0.003). L-FABP-based CI-AKI developed in 8 control patients (26.9%) vs. only 2 patients in the RIPC group (7.7%), suggesting that RIPC prevents CI-AKI. Factors contributing to CI-AKI were analyzed. 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Remote Ischemic Pre-Conditioning Alleviates Contrast Induced Acute Kidney Injury in Patients With Moderate Chronic Kidney Disease
http://hdl.handle.net/10295/2518
http://hdl.handle.net/10295/25184b894c08-47ff-4a94-a908-b84076136f51
名前 / ファイル | ライセンス | アクション |
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ihakukou1074.pdf (921.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-06-27 | |||||
タイトル | ||||||
タイトル | Remote Ischemic Pre-Conditioning Alleviates Contrast Induced Acute Kidney Injury in Patients With Moderate Chronic Kidney Disease | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Contrast-induced acute kidney injury | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Coronary angiography | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liver-type fatty acid-binding protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Remote ischemic preconditioning | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Igarashi, Gen
× Igarashi, Gen× Iino, Kenji× Watanabe, Hiroyuki× Ito, Hiroshi |
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内容記述(抄録) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background: Although remote ischemic preconditioning (RIPC) is shown to preserve kidney function in patients at high risk of contrast-induced acute kidney injury (CI-AKI), the effect in patients at low-moderate risk remains unknown. The preventive effects of RIPC in patients not at high risk of CI-AKI were examined, and biomarkers with anticipated roles in renal protection via RIPC investigated. Methods and Results: Sixty patients who had moderate chronic kidney disease and who underwent angiography were randomly assigned to the control (n=30) or RIPC (intermittent arm ischemia, n=30) group. The baseline characteristics in the 2 groups did not differ significantly. CI-AKI was evaluated by measuring urinary liver-type fatty acidbinding protein (L-FABP). Biomarkers were measured before and 24 and 48 h after angiography. Twenty-four hours after angiography, the percent change in urinary L-FABP level in the RIPC group was significantly smaller than in the control group (41.3±15.6 vs. 159±34.1%, P=0.003). L-FABP-based CI-AKI developed in 8 control patients (26.9%) vs. only 2 patients in the RIPC group (7.7%), suggesting that RIPC prevents CI-AKI. Factors contributing to CI-AKI were analyzed. Neither high-sensitivity C-reactive protein nor pentraxine-3 level differed significantly between the 2 groups, while the percent change in asymmetrical dimethy larginine (ADMA) level and blood derivatives of reactive oxidative metabolite levels were significantly smaller in the RIPC group. Conclusions: RIPC alleviates CI-AKI in patients at low-moderate risk. This effect might be mediated partly by decreasing oxidative stress and plasma ADMA level. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1253/circj.CJ-13-0171 | |||||
書誌情報 |
Circulation Journal 巻 77, 号 12, p. 3037-3044, 発行日 2013-11-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13469843 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11591968 | |||||
出版者 | ||||||
出版者 | Japanese Circulation Society | |||||
著作権等 | ||||||
権利情報 | Japanese Circulation Society | |||||
備考 | ||||||
秋田大学審査学位論文の「Circulation Journal」掲載版 |