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Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide
http://hdl.handle.net/10295/2511
http://hdl.handle.net/10295/251100c4f5cb-df1c-4bd9-a110-53bdc54e12d3
名前 / ファイル | ライセンス | アクション |
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本文 (807.5 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2014-06-23 | |||||
タイトル | ||||||
タイトル | Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
別タイトル | ||||||
その他のタイトル | サリノマイシン細胞周期の遅い細胞を含むメラノーマ・スフェロイドの三酸化ヒ素に対する効果を鋭敏化する | |||||
著者 |
石河, 軌久
× 石河, 軌久× Ishiga, Norihisa |
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内容記述(抄録) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Recurrence after chemotherapy is a major cause of cancer mortality: subsets of tumor cells evade initial chemotherapy or radiotherapy and survive to re-propagate the tumor. To develop a novel therapeutic approach for melanoma, we applied a non-adhesive culture system which developed spheroids mimicking the properties of melanoma in vivo. Subsequently, spheroids involved cells exhibiting clonogenic and slow-cycling properties in addition to chemotherapeutic resistance to doxorubicin. Interestingly, while treatment of spheroids with either salinomycin or As_2O_3 showed limiting effects, a combinatorial treatment was markedly superior to single treatment with each drug. Thus, melanoma spheroids could be a new platform for studying melanoma biology and are likely to provide a clinically relevant target for the novel chemotherapy. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
書誌情報 | 発行日 2014-06-01 | |||||
関連リンク | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10295/2504 | |||||
関連名称 | http://hdl.handle.net/10295/2504 | |||||
備考 | ||||||
秋田大学審査学位論文(秋田医学,40(3/4),p143-p150掲載論文の著者最終稿) | ||||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 11401 | |||||
学位授与機関名 | 秋田大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2014-03-22 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第1077号 |