LAMOTRIGINE-RELATED DISSEMINATED INTRAVASCULAR COAGULATION IS MEDIATED BY ANTICONVULSANT HYPERSENSITIVITY SYNDROME : A PHARMACOEPIDEMIOLOGICAL STUDY
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The relationship between disseminated intravascular coagulation (DIC) and lamotrigine (LTG) use is a controversial topic. We hypothesized that DIC after LTG use is mediated by anticonvulsant hypersensitivity syndrome (AHS), based on our clinical experiences. To examine this hypothesis, a pharmacoepidemiological study was designed using the Japanese Adverse Drug Event Report database (JADER). Twenty-two cases of LTG-related DIC were identified by an exhaustive survey of JADER. AHS triad of fever, skin eruption, and internal organ involvement (indicated by liver dysfunction) were also investigated on each case. Fifty-nine percent of LTGrelated DIC cases had the AHS triad. These results suggest that a distinct etiology, namely AHS or a phenomenon related to this syndrome, is the underlying mechanism of LTG-related DIC. LTG may induce DIC via AHS. More attention should be focused on the risk of DIC with LTG use.
LAMOTRIGINE-RELATED DISSEMINATED INTRAVASCULAR COAGULATION IS MEDIATED BY ANTICONVULSANT HYPERSENSITIVITY SYNDROME : A PHARMACOEPIDEMIOLOGICAL STUDY
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