Purpose
We examined the treatment outcomes,prognostic factors,and toxicities after radiotherapy for stage IIIB uterine cervical cancer.
Methods and Materials
We studied patients with stage IIIB uterine cervical cancer who were both diagnosed and treated with combined external beam radiotherapy(EBRT) and intracavitary brachytherapy(ICBT). We retrospectively analyzed the clinical characteristics(age,primary tumor size,lymph node metastasis,and chemotherapy),5-year overall survival(OS) rate,progressionfree survival(PFS) rate,and late toxicities over grade 3.
Results
A total of 25 patients were enrolled in this study.Overall 23 and 2 patients showed complete and partial response,respectively.The objective response was 100%.The 5-year OS and PFS were 73.4% (95% confidence interval [CI] 55.1-91.6%) and 69% (95% CI 49.5-88.0%), respectively.Primary tumor size ≥40 mm was a prognostic factor for poor OS and PFS (HR : 5.088, p=0.024 and HR : 5.088, p=0.033, respectively). Five patients(20%) developed late toxicities over grade 3 with related radiotherapy.
Conclusions
Local tumor control,OS,PFS,and late toxicity rate in this study were similar to those in previous reports. A bulky tumor was identified as a prognostic factor.
RADIATION THERAPY FOR STAGE ⅢB UTERINE CERVICAL CANCER AT OUR INSTITUTION : TREATMENT OUTCOMES AND PROGNOSTIC FACTORS
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