Forced-swimming gives mouse continuous stress. Mouse given the stress shows different
stress-coping behaviors, climbing for escaping from the stressful situation and motionlessness for
keeping the physical strength. The former is induced by humoral GalNacα1-3GalNAc-ceramide
fractioned with 150 mM NaCl and the latter is done by other humoral lipid fractioned with 100
mM NaCl. In the present study, the authors investigate productions of these humoral lipids of
mouse given forced swimming stress in CO2-bubble bathing. GalNacα1-3GalNAc-ceramide reactivity
was increased in serum of mouse given the stress in microbubble CO2 bathing and in serum
of mouse given the stress in pressured CO2 bathing. Motionlessness duration was increased in
mouse treated with 100 mM NaCl fraction of mouse given the stress in microbubble CO2 bathing,
but was not in mouse treated with the fraction of mouse given the stress in pressured CO2
bathing. These suggest that CO2 bathing induced stress-coping effect on mice given forcedswimming
stress, and that CO2-bubble form was related to quality of the effect.
マイクロバブル炭酸浴のストレスコーピング効果
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