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To\ninvestigate the effect of OMSO on the differentiation of HL-60 cells induced by\n1α,25-dihydroxyvitamin D3, three variant clones (ORHL-1, ORHL-2 and ORHL-3\ncells) resistant to 1α,25-dihydroxyvitamin D3 were iso1α,ted from a OMSO-resistant\ncell clone (ORHL) ofHL-60 cells. These variant clones were insusceptible to 1α,25-\ndihydroxyvitamin D3 or OMSO, when based on the criteria of cell growth, expression\nof antigens for human monocyte specific (OKMS) or human granulocyte specific\n(80H5) monoclona1α,ntibodies, NBT-reducing activity, phagocytosis, nonspecific\nesterase activity, and cathepsin Band 1α,ctivities. The variant clones, ORHL-1\nand ORHL-3, which were insusceptible to 1α,25-dihydroxyvitamin D3 or OMSO\nalone, were induced to differentiate into macrophage-like cells on simultaneous\ntreatment with 1α,25-dihydroxyvitamin D3 and OMSO. Furthermore, ORHL-1 but\nnot ORHL-3 differentiated into macrophage-like cells on I-day treatment with\n1α,,25-dihydroxyvitamin D3 followed by 3-day treatment with OMSO. The other\nvariant, ORHL-2, did not differentiate with any combination of 1α,25-dihydroxyvitamin\nD3 and OMSO. These results suggest that OMSO promotes the differentiation\nof HL-60 cells initiated by 1α,,25-dihydroxyvitamin D3 into macrophages at\nvarious stages of differentiation.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Biomedical Research Foundation"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.2220/biomedres.7.311", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_25": {"attribute_name": "関連リンク", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://doi.org/10.2220/biomedres.7.311", "subitem_relation_type_select": "DOI"}}]}, "item_10001_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00110128", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03886107", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "SENOO, Haruki"}], "nameIdentifiers": [{"nameIdentifier": "9948", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "WAKE, Kenjiro"}], "nameIdentifiers": [{"nameIdentifier": "9949", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MOMOI, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "9950", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YOSHIKURA, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "9951", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-02-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "senoo5.pdf", "filesize": [{"value": "800.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 800500.0, "url": {"label": "senoo5.pdf", "url": "https://air.repo.nii.ac.jp/record/2703/files/senoo5.pdf"}, "version_id": "23ebf316-12f0-46a1-ac9b-cc90cfe385a1"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ISOLATION AND CHARACTERIZATION OF CLONES OF A HUMAN LEUKEMIA CELL LINE (HL-60 CELLS) RESISTANT TO 1α,25-DIHYDROXYVITAMIN D3 AND DIMETHYL SULFOXIDE", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ISOLATION AND CHARACTERIZATION OF CLONES OF A HUMAN LEUKEMIA CELL LINE (HL-60 CELLS) RESISTANT TO 1α,25-DIHYDROXYVITAMIN D3 AND DIMETHYL SULFOXIDE"}]}, "item_type_id": "10001", "owner": "3", "path": ["940"], "permalink_uri": "http://hdl.handle.net/10295/3063", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-04-20"}, "publish_date": "2016-04-20", "publish_status": "0", "recid": "2703", "relation": {}, "relation_version_is_last": true, "title": ["ISOLATION AND CHARACTERIZATION OF CLONES OF A HUMAN LEUKEMIA CELL LINE (HL-60 CELLS) RESISTANT TO 1α,25-DIHYDROXYVITAMIN D3 AND DIMETHYL SULFOXIDE"], "weko_shared_id": 3}
ISOLATION AND CHARACTERIZATION OF CLONES OF A HUMAN LEUKEMIA CELL LINE (HL-60 CELLS) RESISTANT TO 1α,25-DIHYDROXYVITAMIN D3 AND DIMETHYL SULFOXIDE
http://hdl.handle.net/10295/3063
http://hdl.handle.net/10295/3063cd2eeda5-f7ae-417a-8846-4dffc02fda29
名前 / ファイル | ライセンス | アクション |
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senoo5.pdf (800.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-04-20 | |||||
タイトル | ||||||
タイトル | ISOLATION AND CHARACTERIZATION OF CLONES OF A HUMAN LEUKEMIA CELL LINE (HL-60 CELLS) RESISTANT TO 1α,25-DIHYDROXYVITAMIN D3 AND DIMETHYL SULFOXIDE | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
SENOO, Haruki
× SENOO, Haruki× WAKE, Kenjiro× MOMOI, Takashi× YOSHIKURA, Hiroshi |
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内容記述(抄録) | ||||||
内容記述タイプ | Other | |||||
内容記述 | We have previously demonstrated that HL-60 cells pretreated with 1α,25-dihydroxyvitamin D3 at the stage of commitment were induced to differentiate into macrophage- like cells by dimethyl sulfoxide (OMSO) at the stage of promotion (15). To investigate the effect of OMSO on the differentiation of HL-60 cells induced by 1α,25-dihydroxyvitamin D3, three variant clones (ORHL-1, ORHL-2 and ORHL-3 cells) resistant to 1α,25-dihydroxyvitamin D3 were iso1α,ted from a OMSO-resistant cell clone (ORHL) ofHL-60 cells. These variant clones were insusceptible to 1α,25- dihydroxyvitamin D3 or OMSO, when based on the criteria of cell growth, expression of antigens for human monocyte specific (OKMS) or human granulocyte specific (80H5) monoclona1α,ntibodies, NBT-reducing activity, phagocytosis, nonspecific esterase activity, and cathepsin Band 1α,ctivities. The variant clones, ORHL-1 and ORHL-3, which were insusceptible to 1α,25-dihydroxyvitamin D3 or OMSO alone, were induced to differentiate into macrophage-like cells on simultaneous treatment with 1α,25-dihydroxyvitamin D3 and OMSO. Furthermore, ORHL-1 but not ORHL-3 differentiated into macrophage-like cells on I-day treatment with 1α,,25-dihydroxyvitamin D3 followed by 3-day treatment with OMSO. The other variant, ORHL-2, did not differentiate with any combination of 1α,25-dihydroxyvitamin D3 and OMSO. These results suggest that OMSO promotes the differentiation of HL-60 cells initiated by 1α,,25-dihydroxyvitamin D3 into macrophages at various stages of differentiation. |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2220/biomedres.7.311 | |||||
書誌情報 |
Biomedical Research 巻 7, 号 5, p. 311-319, 発行日 1986 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03886107 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00110128 | |||||
出版者 | ||||||
出版者 | Biomedical Research Foundation | |||||
関連リンク | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://doi.org/10.2220/biomedres.7.311 |